A database of CYP3A4-mediated drug interaction on anti-HIV and anti-TB drugs

Cytochrome P450

Drug-drug interactions




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Accession Number Drug Name Protein Target Drug Structure Complex structure of CYP3A4 and drug
PU_CYP0001 Ritonavir HIV protease inhibitor
PU_CYP0018 Isoniazid Isoniazid inhibits InhA, the enoyl reductase from
PU_CYP0002 Amprenavir HIV protease inhibitor
PU_CYP0016 Rifapentine DNA-dependent RNA Polymerase
PU_CYP0014 Maraviroc Entry Inhibitor - CCR5 co-receptor antagonist
PU_CYP0012 Efavirenz Non-nucleoside reverse transcriptase inhibitor
PU_CYP0010 Atazanavir HIV protease inhibitor
PU_CYP0008 Fosamprenavir HIV protease inhibitor
PU_CYP0004 Indinavir HIV protease inhibitor
PU_CYP0005 Saquinavir HIV protease inhibitor
PU_CYP0006 Nelfinavir HIV protease inhibitor
PU_CYP0019 Pyrazinamide Pyrazinamide is an important sterilizing pro-drug
PU_CYP0017 Rifabutin DNA-dependent RNA Polymerase
PU_CYP0003 Tipranavir HIV protease inhibitor
PU_CYP0015 Rifampin DNA-dependent RNA Polymerase
PU_CYP0013 Etravirine Non-nucleoside reverse transcriptase inhibitor
PU_CYP0011 Delavirdine Non-nucleoside reverse transcriptase inhibitor
PU_CYP0009 Darunavir HIV protease inhibitor
PU_CYP0007 Lopinavir HIV protease inhibitor

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